A research team from the Medical University of South Carolina recently discovered an efficient way to purify liver cells derived from induced pluripotent stem cells (iPSCs), which are stem cells that are created directly from adult cells. This could potentially lead to the treatment of patients with liver diseases with liver cells that are not mutate that have been derived from their own stem cells. In previous trials, IPSCs would not mature into liver-like cells, and they were not pure enough to be reliable in helping scientists find the subtle genetic variations that could have been causing diseases. Because of this, the group turned to chemoproteomic cell surface capture (CSC) technology.
With this technology, researchers were able to map the most highly produced protein on the surface of liver cells during the final stages of separation of a stem cell to into a liver cell. This protein was then targeted with an antibody which labeled with a marker to differentiate mature liver cells from the rest. The results were mature, liver-like cells which could be observed for obscure genetic anomalies that cause disease in the liver without the risk of having varying results due to impure cells. This could eventually lead to more advancements in disease identifying research, but, as of now, these liver-like cells that are the purest yet could be a major progression in treatment of liver diseases.
Read the whole article published as a Stem Cell Report on: http://phys.org/news/2016-08-purest-liver-like-cells-pluripotent-stem.html
Author: Harsha Patil
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